Resumen

Central nervous system tumors are a major cause of morbidity and mortality. Outside of brain metastasis, low and high grade gliomas are the most common intrinsic brain tumors. The optimal treatment of malignant gliomas has developed through the last years. Early management with radical surgery and adjuvant chemotherapy and radiotherapy are the standard protocol. Prognostic factors involved are age at presentation, histology, molecular biology characteristics, Karnofsky Score (KS), surgical results and adjuvant therapy. Once age, histology, tumor behavior and KS are independent factors associated to patient and adjuvant therapy is usually standard for all patients, surgery is the one in which medical management can perform greatest change in evolution of disease. Therefore, surgical results with maximal resection of neoplastic tissue and minimal risk of functional neurological deficit, is the aim in malignant glioma surgery. Surgical act involves a complex structure which demands planning, knowledge of cerebral anatomy and physiology, and technical execution. A special anatomic and physiological knowledge must involve the white matter, once malignant gliomas spread through such structures.

Palabras clave: Malignant gliomas treatment complications.

2015-07-08   |   1,088 visitas   |   Evalua este artículo 0 valoraciones

Vol. 21 Núm.3. Septiembre 2014 Pags. 305-310 Neurocien Colom 2014; 21(3)